WebSep 10, 2024 · They appeared at the transition from the Late Neolithic period, around 4000 B.C., to the Early Bronze Age during the third millennium B.C. somewhere in Western Europe. They were distinguished by ...
The cystic fibrosis heterozygote--advantage in surviving …
Web9 rows · Sep 1, 2015 · Cystic fibrosis and cholera: Mutations in a gene encoding a chloride channel (CFTR) Excessive ... Cholera is an acute illness characterized by sudden onset of watery diarrhea with a rice water appearance (flakes of mucus and epithelial cells) and a fishy odor (37). The onset of the illness has an incubation period varying from 6 h to 5 days. The major complication of infection by cholera is massive loss of body … See more Vibrios are one of the most common organisms in surface waters of the world (both marine and freshwater) (37). Vibrios are acquired by eating contaminated food or drinking contaminated water and are transmitted from … See more Cholera toxin has binding and enzymatically active subunits that activate the adenylate cyclase system of cells in the intestinal mucosa leading to increased levels of intracellular … See more One of the major problems with CF for many individuals is blockage of the outflow of digestive enzymes from the exocrine pancreas into the small intestine and the resultant pancreatitis that can lead to the cystic changes in the … See more The major prevention against epidemic cholera is a safe water supply, good sanitation and disposal of excreta, and safe food (37). Thus effective control measures include … See more include和-include
Cystic fibrosis - Wikipedia, the free encyclopedia
WebRecently a heterozygote advantage was suggested to explain the high incidence (1:25 carrier individuals in Europeans) of the cystic fibrosis gene. This selective advantage was speculated to be due to a high resistance to chloride-secreting diarrhea, including cholera. Up to now the major efforts to test directly this hypothesis have been limited to animal … WebCystic fibrosis (CF) is a genetic disorder that causes problems with breathing and digestion. CF affects about 35,000 people in the United States. People with CF have mucus that is too thick and sticky, which. blocks airways and leads to lung damage; traps germs and makes infections more likely; and. prevents proteins needed for digestion from ... WebNov 1, 1991 · Abstract. Cystic fibrosis (CF) is the most common fatal genetic disorder of caucasians. While it has been hypothesized that there is a CF heterozygote advantage which allowed the gene to achieve such high prevalence, the nature of that advantage remains a mystery. The recent identification and sequencing of the CF gene has … include和include_once的区别