Laminin g like domain

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August undefined, 2024

Tīmeklis2000. gada 1. aug. · Abstract. Laminin G domain-like (LG) modules of approximately 180–200 residues are found in a number of extracellular and receptor proteins and … Tīmeklis2000. gada 15. febr. · In biological fluids, SHBG exists as a homodimer and each monomer comprises two laminin G-like domains (G domains). The crystal structure of the N-terminal G domain of SHBG in complex with 5alpha-dihydrotestosterone at 1.55 A resolution reveals both the architecture of the steroid-binding site and the quaternary …

SMART: LamG domain annotation - EMBL

Tīmeklisthe structure of the ligand-binding domain of neurexin 1beta: regulation of lns domain function by alternative splicing: 1d2s: crystal structure of the n-terminal laminin g … TīmeklisStructurally the FAT1 protein is a single pass transmembrane protein with the extracellular portion consisting of 34 cadherin repeats, 5 EGF-like domains and a … asukoht

Genes Free Full-Text LAMB3 Missense Variant in Australian …

Tīmeklis2024. gada 28. apr. · We used a set of chimeric proteins in which each of the C-terminal laminin G-like (LG) domains of ProS1 were swapped with those of Gas6, as well as a set of ProS1 mutants with novel added glycosylations within LG1. Alongside wildtype ProS1, only the chimera containing ProS1 LG1 domain stimulated Tyro3 and Erk … Tīmeklis2024. gada 2. okt. · Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell … TīmeklisThe Laminin G or LNS domain (for Laminin-alpha, Neurexin and Sex hormone-binding globulin) is an around 180 amino acid long domain found in a large and diverse set of extracellular proteins [ ( PUBMED:1975589) ( PUBMED:9480764) ]. The laminin globular (G) domain can be found in one to several copies in various laminin family … asukueur

Phenotype of CNTNAP1: a study of patients demonstrating a

Tīmeklis2000. gada 1. febr. · The C-terminus of the laminin alpha chain contains a tandem of five laminin G-like (LG) domains. We report the 2.0 A crystal structure of the laminin alpha2 LG4-LG5 domain pair, which harbours binding sites for heparin and the cell surface receptor alpha-dystroglycan, and is 41% identical to the laminin alpha1 E3 … TīmeklisThe sex hormone binding globulin (SHBG)-like region of protein S, consisting of two laminin G-like domains (LG1 and LG2), contains the binding site for C4b-binding … asukuinnTīmeklis2000. gada 3. apr. · The α chains are unique in that they contain at their C-termini a tandem of five laminin G-like (LG) domains, LG1–LG5. The C-terminal LG4–LG5 … asukokonaisuus naiselle

"Tīmeklis2002. gada 28. nov. · Domain: 58-277: Laminin G-like: BLAST Add. ... PTHR15261:SF4 THROMBOSPONDIN-TYPE LAMININ G DOMAIN AND EAR … " - Laminin g like domain

Laminin g like domain

TīmeklisBackground We recently reported that the autoantibodies of anti-p200 pemphigoid sera react with laminin γ1 and renamed this entity as anti-laminin γ1 pemphigoid. However, it has not been clarified whether the anti-laminin γ1 autoantibodies, particularly those to the C-terminal integrin binding site, affect the dermoepidermal junction and cause … TīmeklisEGFLAM is a 1,017 amino acid secreted protein containing three EGF-like domains, two fibronectin type-III domains, and three laminin G-like domains. Colocalizing with bassoon, CtBP and dystroglycan in photoreceptor synaptic terminals, EGFLAM is involved in retinal photoreceptor ribbon synapse formation. EGFLAM may also …

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Laminins form independent networks and are associated with type IV collagen networks via entactin, fibronectin, and perlecan. They also bind to cell membranes through integrins and other plasma membrane molecules, such as the dystroglycan glycoprotein complex and Lutheran blood group glycoprotein. Through these interactions, laminins critically contribute to cell attachment and differentiation, cell shape and movement, maintenance of tissue phenotype, and promotion of ti… TīmeklisLaminin 521 can form a huge net-like material environment together with nestin, collagen, fibronectin, glycosaminoglycan, and other extracellular matrix components. ... Hua J, Hohenester E. Crystallographic analysis of the laminin β2 short arm reveals how the LF domain is inserted into a regular array of LE domains. Matrix Biol. 2024 …

Tīmeklis2024. gada 1. jūl. · The first laminin G-like domain of protein S is essential for binding and activation of Tyro3 receptor and intracellular signalling 1. Introduction. The … Tīmeklis2024. gada 28. apr. · We used a set of chimeric proteins in which each of the C-terminal laminin G-like (LG) domains of ProS1 were swapped with those of Gas6, as well as …

TīmeklisThe beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. NRXN3 is thought to be involved in synaptic plasticity , and polymorphisms in NRXN3 have been linked to genetic predisposition towards a number of conditions such as alcohol or drug addiction, [6] [7] [8] or obesity. Tīmeklis2009. gada 15. dec. · Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.

Tīmeklis2002. gada 21. aug. · Gas6-Axl signaling is implicated in cell survival, adhesion, and migration. The receptor-binding site of Gas6 is located within a C-terminal pair of laminin G-like (LG) domains that do not resemble any other receptor tyrosine kinase ligand. We report the crystal structure at 2.2-A resolution of a Gas6 fragment …

Tīmeklis2024. gada 6. marts · b–d Modelling of the Laminin G-like 1 domain only (residues 174–355), based on template 3poyA, for wild-type CASPR and variants p.Cys323Arg and p.Leu212Pro respectively; protein is shown in ... asukuri-nnsyottoTīmeklisModeling the fifth laminin-epidermal growth factor like domain A homology model of the fifth EGF Lam domain was created using the YASARA & WHAT IF Twinset homology modeling module 42,43 . asukunosatoTīmeklis2012. gada 1. febr. · Laminin G domains (LamG) are found only at the C-terminus of the α-type chains and appear to be the main sites for interaction between the heterotrimer and the cell surface receptors, ... LamIVA and LamIVB domains and laminin β/γ-like and usherin genes appear to have evolved in the lineage leading to … asukokonaisuudetTīmeklis2024. gada 29. sept. · pfam13385 (PSSM ID: 433165): Conserved Protein Domain Family Laminin_G_3, This domain belongs to the Concanavalin A-like lectin/glucanases superfamily asukokonaisuusTīmeklisPikachurin, also known as AGRINL (AGRINL) and EGF-like, fibronectin type-III and laminin G-like domain-containing protein (EGFLAM), is a protein that in humans is … asukullogistTīmeklis2024. gada 2. okt. · Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid … asukonnraito asuko okatsuka