Photocaged probes for spatiotemporal imaging
WebEarly cancer diagnosis is of great significance to relative cancer prevention and clinical therapy, and it is crucial to efficiently recognize cancerous tumor sites at the molecular … WebJun 15, 2024 · Benefitting from the labeled TP fluorophore, the near-infrared (NIR) excited probe has the capability of TP imaging of Zn²⁺ in living cells and tissue with a deep tissue penetration up to 160 µm.
Photocaged probes for spatiotemporal imaging
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WebDec 15, 2024 · This approach enables protein glycation to be controlled with spatiotemporal precision within live cells and expands the chemical toolbox needed to elucidate the roles of glycated proteins across various pathologies. ... Photocaged dicarbonyl probe provides spatiotemporal control over protein glycation A. K. Hurben, P. Ge, ... WebApr 11, 2024 · 2024 年 12 月 22 日，黄晋团队在 Nucleic Acids Research 上发表了一篇研究论文，题为《光控放大的FRET纳米耀斑：时空可控的、mRNA 驱动的纳米机器用于活细胞内微小RNA的精准、灵敏成像》（Photocaged amplified FRET nanoflares: spatiotemporal controllable of mRNA-powered nanomachines for ...
WebImaging of species in living organisms with high spatiotemporal resolution is essential for understanding biological processes. While functional nucleic acids (FNAs), such as catalytic nucleic acids and aptamers, have emerged as effective sensors for a wide range of molecules, photocaged control of these FNAs has played a key role in translating them … WebJul 8, 2024 · The U.S. Department of Energy's Office of Scientific and Technical Information
WebJun 7, 2024 · To improve detection accuracy and achieve on-demand sensing, herein, we developed photocaged FRET nanoflares for spatiotemporal microRNA imaging in living … WebThe toolbox of RNA imaging reporters is continuously expanding, enabling finer investigations of the spatiotemporal control of gene expression, but several challenges still need to be tackled. For instance, RNA imaging in fixed cells (i.e., using smFISH-based approaches) can now be applied at the scale of the whole transcriptome.
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Webpowerful tool to precisely control the activation of therapeutic reagents and imaging probes in vitro and in vivo, mostly attributed to its unique properties including minimally invasive capability and highly spatiotemporal resolution. Although it has achieved initial success, the onventional c ... these photocaged probes will be rapidly ... famelytreeWebJul 1, 2024 · Lastly, we give some examples to display the recent applications of photocaged peptide probes interactions, protein misfolding, post-translational modifications and peptide drug delivery. 2. The chemistry of peptide photocaging. Several common features are shared among most PPGs [2, 7]. Yet for peptide photocaging, additional … famel zündapp z3WebAug 1, 2024 · Imaging of species in living organisms with high spatiotemporal resolution is essential for understanding biological processes. While functional nucleic acids (FNAs), … fa melzerWebApr 11, 2024 · To investigate the spatiotemporal activation of GLP1R and GLPLight1, a photocaged derivative of GLP-1 was envisioned. To ensure that the photocaged GLP-1 derivative does not activate GLP1R or GLPLight1 prior to uncaging (i.e. in the dark), the photocage must be located on or near GLP-1 regions that are essential for binding. hl club playa blanca 2 bedroom bungalowWebMay 12, 2024 · Photocaged DNAzymes can be activated by light for sensing purposes that need spatial and temporal resolution. Studying complex biological processes requires logic photocontrol, but unfortunately all the literature-reported photocaged DNAzymes working in live cells cannot be selectively controlled by light irradiation at different wavelengths. hl company kanpurWebIn 2015, we proposed FRET nanoflares for intracellular molecular (RNA, H+, and K+) detection. To improve detection accuracy and achieve on-demand sensing, herein, we … famel z2 olxWebvalidate the photorelease of photocaged TAM,22 it required near toxic concentrations (Z8 mM). Consequently, our initial test of ONB–4OHT compounds used similarly high concentrations (5 mM), and we often observed reduced cell viability after treatment (Fig. 1d). Therefore, we sought to re-optimize condi-tions for use with photocaged 4OHT. hlc parking